7B9L
MEK1 in complex with compound 23
Summary for 7B9L
Entry DOI | 10.2210/pdb7b9l/pdb |
Descriptor | Dual specificity mitogen-activated protein kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ~{N}-(4-methoxyphenyl)-2-[(2~{S})-3-oxidanylidenethiomorpholin-2-yl]ethanamide, ... (7 entities in total) |
Functional Keywords | kinase, allosteric, fragments, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 74925.85 |
Authors | |
Primary citation | Di Fruscia, P.,Edfeldt, F.,Shamovsky, I.,Collie, G.W.,Aagaard, A.,Barlind, L.,Borjesson, U.,Hansson, E.L.,Lewis, R.J.,Nilsson, M.K.,Oster, L.,Pemberton, J.,Ripa, L.,Storer, R.I.,Kack, H. Fragment-Based Discovery of Novel Allosteric MEK1 Binders. Acs Med.Chem.Lett., 12:302-308, 2021 Cited by PubMed: 33603979DOI: 10.1021/acsmedchemlett.0c00563 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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