7B42
Crystal structure of c-MET bound by compound 8
Summary for 7B42
Entry DOI | 10.2210/pdb7b42/pdb |
Descriptor | Hepatocyte growth factor receptor, 3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine (3 entities in total) |
Functional Keywords | c-met, kinase, folded p-loop, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34161.65 |
Authors | Collie, G.W. (deposition date: 2020-12-02, release date: 2020-12-09, Last modification date: 2024-05-01) |
Primary citation | Collie, G.W.,Michaelides, I.N.,Embrey, K.,Stubbs, C.J.,Borjesson, U.,Dale, I.L.,Snijder, A.,Barlind, L.,Song, K.,Khurana, P.,Phillips, C.,Storer, R.I. Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12:162-167, 2021 Cited by PubMed: 33488978DOI: 10.1021/acsmedchemlett.0c00392 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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