7B0V
Crystal Structure of human monoamine oxidase B in complex with (E)-3-phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one
Summary for 7B0V
Entry DOI | 10.2210/pdb7b0v/pdb |
Descriptor | Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, (E)-3-phenyl-1-(3-(trifluoromethyl)phenyl)prop-2-en-1-one, ... (6 entities in total) |
Functional Keywords | monoamine oxidase, drug target, neurodegeneration, flavin, chalcone, mitochondrial membrane, flavoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 120656.36 |
Authors | Iacovino, L.G.,Binda, C. (deposition date: 2020-11-23, release date: 2021-11-03, Last modification date: 2024-01-31) |
Primary citation | Iacovino, L.G.,Pinzi, L.,Facchetti, G.,Bortolini, B.,Christodoulou, M.S.,Binda, C.,Rastelli, G.,Rimoldi, I.,Passarella, D.,Di Paolo, M.L.,Dalla Via, L. Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B. Acs Med.Chem.Lett., 12:1151-1158, 2021 Cited by PubMed: 34262643DOI: 10.1021/acsmedchemlett.1c00238 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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