7AYH
Crystal structure of Aurora A in complex with 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-one derivative (compound 2c)
Summary for 7AYH
Entry DOI | 10.2210/pdb7ayh/pdb |
Descriptor | Aurora kinase A, 7-[2-[(4-methoxyphenyl)amino]pyrimidin-4-yl]-1,3,4,5-tetrahydro-1-benzazepin-2-one (2 entities in total) |
Functional Keywords | kinase, kinase inhibitor, aurora kinase, stk6, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33309.19 |
Authors | Chaikuad, A.,Karatas, M.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-12, release date: 2021-01-13, Last modification date: 2024-01-31) |
Primary citation | Karatas, M.,Chaikuad, A.,Berger, B.,Kubbutat, M.H.G.,Totzke, F.,Knapp, S.,Kunick, C. 7-(2-Anilinopyrimidin-4-yl)-1-benzazepin-2-ones Designed by a "Cut and Glue" Strategy Are Dual Aurora A/VEGF-R Kinase Inhibitors. Molecules, 26:-, 2021 Cited by PubMed: 33799460DOI: 10.3390/molecules26061611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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