7AXQ
Structure of the cryo-trapped WDR5:CS-VIP8 cocrystal after illumination at 405 nm and 180 K
Summary for 7AXQ
Entry DOI | 10.2210/pdb7axq/pdb |
Related | 7AXP |
Descriptor | WD repeat-containing protein 5, CS-VIP8 (3 entities in total) |
Functional Keywords | wdr5, cyclic strained visible-light photoswitches, mll1 complex disruption, inhibition of hematopoiesis, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 37579.40 |
Authors | Werel, L.,Essen, L.-O. (deposition date: 2020-11-10, release date: 2021-12-15, Last modification date: 2024-07-10) |
Primary citation | Albert, L.,Nagpal, J.,Steinchen, W.,Zhang, L.,Werel, L.,Djokovic, N.,Ruzic, D.,Hoffarth, M.,Xu, J.,Kaspareit, J.,Abendroth, F.,Royant, A.,Bange, G.,Nikolic, K.,Ryu, S.,Dou, Y.,Essen, L.O.,Vazquez, O. Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8:57-66, 2022 Cited by PubMed: 35106373DOI: 10.1021/acscentsci.1c00434 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.562 Å) |
Structure validation
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