7AV0
LTA4 hydrolase in complex with compound R(13)
Summary for 7AV0
Entry DOI | 10.2210/pdb7av0/pdb |
Descriptor | Leukotriene A-4 hydrolase, ZINC ION, ACETATE ION, ... (7 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 70599.53 |
Authors | Srinivas, H. (deposition date: 2020-11-03, release date: 2021-02-17, Last modification date: 2024-01-31) |
Primary citation | Markert, C.,Thoma, G.,Srinivas, H.,Bollbuck, B.,Luond, R.M.,Miltz, W.,Walchli, R.,Wolf, R.,Hinrichs, J.,Bergsdorf, C.,Azzaoui, K.,Penno, C.A.,Klein, K.,Wack, N.,Jager, P.,Hasler, F.,Beerli, C.,Loetscher, P.,Dawson, J.,Wieczorek, G.,Numao, S.,Littlewood-Evans, A.,Rohn, T.A. Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64:1889-1903, 2021 Cited by PubMed: 33592148DOI: 10.1021/acs.jmedchem.0c01955 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report