7A7H

Crystal structure of PPARgamma in complex with compound TK90

Summary for 7A7H

Entry DOI	10.2210/pdb7a7h/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (2~{R})-2-[[4-[[4-methoxy-2-(trifluoromethyl)phenyl]methylcarbamoyl]phenyl]methyl]butanoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	complex, structural genomics, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32139.26
Authors	Ni, X.,Kirchner, T.,Proschak, E.,Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-08-28, release date: 2021-08-04, Last modification date: 2024-01-31)
Primary citation	Hartmann, M.,Bibli, S.I.,Tews, D.,Ni, X.,Kircher, T.,Kramer, J.S.,Kilu, W.,Heering, J.,Hernandez-Olmos, V.,Weizel, L.,Scriba, G.K.E.,Krait, S.,Knapp, S.,Chaikuad, A.,Merk, D.,Fleming, I.,Fischer-Posovszky, P.,Proschak, E. Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPAR gamma Modulator. J.Med.Chem., 64:2815-2828, 2021 Cited by PubMed: 33620196 DOI: 10.1021/acs.jmedchem.0c02063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation