6ZYF

Notum_Ghrelin complex

Summary for 6ZYF

• Entry DOI: 10.2210/pdb6zyf/pdb
• Descriptor: Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, [(2~{S})-2-azanyl-3-oxidanylidene-propyl] octanoate, ... (5 entities in total)
• Functional Keywords: notum ghrelin, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 88099.43

Authors

Zhao, Y.,Jones, E.Y. (deposition date: 2020-07-31, release date: 2021-03-10, Last modification date: 2024-11-20)

Primary citation

Zhao, Y.,Schuhmacher, L.N.,Roberts, M.,Kakugawa, S.,Bineva-Todd, G.,Howell, S.,O'Reilly, N.,Perret, C.,Snijders, A.P.,Vincent, J.P.,Jones, E.Y.
Notum deacylates octanoylated ghrelin.
Mol Metab, 49:101201-101201, 2021

PubMed Abstract: The only proteins known to be modified by O-linked lipidation are Wnts and ghrelin, and enzymatic removal of this post-translational modification inhibits ligand activity. Indeed, the Wnt-deacylase activity of Notum is the basis of its ability to act as a feedback inhibitor of Wnt signalling. Whether Notum also deacylates ghrelin has not been determined.

PubMed: 33647468
DOI: 10.1016/j.molmet.2021.101201

Experimental method

X-RAY DIFFRACTION (2.19 Å)