6ZYA

Extended human uromodulin filament core at 3.5 A resolution

6ZYA の概要

• エントリーDOI: 10.2210/pdb6zya/pdb
• 関連するPDBエントリー: 6SZ5
• EMDBエントリー: 11388
• 分子名称: Uromodulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: uromodulin, umod, thp, immunoglobulin-like fold, tamm-horsfall protein, glycoprotein, zp module, zona pellucida, fold complementation, beta-strand complementation, cryosparc, filament, soluble adhesion antagonist, antimicrobial protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 71481.19

構造登録者

Stanisich, J.J.,Zyla, D.,Afanasyev, P.,Xu, J.,Pilhofer, M.,Boeringer, D.,Glockshuber, R. (登録日: 2020-07-31, 公開日: 2020-09-02)

• 主引用文献: Stanisich, J.J.,Zyla, D.S.,Afanasyev, P.,Xu, J.,Kipp, A.,Olinger, E.,Devuyst, O.,Pilhofer, M.,Boehringer, D.,Glockshuber, R.; The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.; Elife, 9:-, 2020; PubMed: 32815518; DOI: 10.7554/eLife.60265

実験手法

ELECTRON MICROSCOPY (3.5 Å)