Summary for 6ZWP
| Entry DOI | 10.2210/pdb6zwp/pdb |
| Descriptor | Mitogen-activated protein kinase 14, 5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[(4-fluorophenyl)amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide (3 entities in total) |
| Functional Keywords | kinase, inhibitor, p38a, structural genomics, structural genomics consortium, sgc, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 41991.91 |
| Authors | Schroeder, M.,Roehm, S.,Knapp, S.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Structural Genomics Consortium (SGC) (deposition date: 2020-07-28, release date: 2020-08-12, Last modification date: 2024-01-31) |
| Primary citation | Rohm, S.,Schroder, M.,Dwyer, J.E.,Widdowson, C.S.,Chaikuad, A.,Berger, B.T.,Joerger, A.C.,Kramer, A.,Harbig, J.,Dauch, D.,Kudolo, M.,Laufer, S.,Bagley, M.C.,Knapp, S. Selective targeting of the alpha C and DFG-out pocket in p38 MAPK. Eur.J.Med.Chem., 208:112721-112721, 2020 Cited by PubMed: 33035818DOI: 10.1016/j.ejmech.2020.112721 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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