6ZW2

Crystal structure of OXA-10loop48 in complex with hydrolyzed meropenem

Summary for 6ZW2

• Entry DOI: 10.2210/pdb6zw2/pdb
• Related: 6ZRG 6ZRH 6ZRI 6ZRJ 6ZRP
• Descriptor: Beta-lactamase, 1,2-ETHANEDIOL, (2S,3R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfan yl-3-methyl-2,3-dihydro-1H-pyrrole-5-carboxylic acid, ... (6 entities in total)
• Functional Keywords: beta-lactamase, oxa-10loop48, carbapenem, meropenem, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 56674.20

Authors

Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Mangani, S.,Docquier, J.D. (deposition date: 2020-07-27, release date: 2021-08-11, Last modification date: 2024-01-31)

• Primary citation: Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Mangani, S.,Docquier, J.D.; Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)