6ZUV

Notum fragment 286

6ZUV の概要

• エントリーDOI: 10.2210/pdb6zuv/pdb
• 分子名称: Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: wnt notum inhibitor complex, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44760.57

構造登録者

Zhao, Y.,Jones, E.Y. (登録日: 2020-07-23, 公開日: 2020-11-11, 最終更新日: 2024-01-31)

• 主引用文献: Mahy, W.,Willis, N.J.,Zhao, Y.,Woodward, H.L.,Svensson, F.,Sipthorp, J.,Vecchia, L.,Ruza, R.R.,Hillier, J.,Kjaer, S.,Frew, S.,Monaghan, A.,Bictash, M.,Salinas, P.C.,Whiting, P.,Vincent, J.P.,Jones, E.Y.,Fish, P.V.; 5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.; J.Med.Chem., 63:12942-12956, 2020; PubMed: 33124429; DOI: 10.1021/acs.jmedchem.0c01391

実験手法

X-RAY DIFFRACTION (1.54 Å)