6ZTC

CRYSTAL STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE IN COMPLEX WITH FRAGMENT 1A AT 1.84A RESOLUTION.

6ZTC の概要

• エントリーDOI: 10.2210/pdb6ztc/pdb
• 分子名称: Hematopoietic prostaglandin D synthase, GLUTATHIONE, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: prostaglandin biosynthesis, fatty acid biosynthesis, prostaglandin d2 synthase, pgds, asthma, cytoplasm, isomerase, lipid synthesis
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48317.61

構造登録者

Somers, D.O. (登録日: 2020-07-17, 公開日: 2021-07-28, 最終更新日: 2024-05-01)

• 主引用文献: Schulte, C.A.,Deaton, D.N.,Diaz, E.,Do, Y.,Gampe, R.T.,Guss, J.H.,Hancock, A.P.,Hobbs, H.,Hodgson, S.T.,Holt, J.,Jeune, M.R.,Kahler, K.M.,Kramer, H.F.,Le, J.,Mortenson, P.N.,Musetti, C.,Nolte, R.T.,Orband-Miller, L.A.,Peckham, G.E.,Petrov, K.G.,Pietrak, B.L.,Poole, C.,Price, D.J.,Saxty, G.,Shillings, A.,Smalley Jr., T.L.,Somers, D.O.,Stewart, E.L.,Stuart, J.D.,Thomson, S.A.; A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.; Bioorg.Med.Chem.Lett., 47:128113-128113, 2021; PubMed: 33991628; DOI: 10.1016/j.bmcl.2021.128113

実験手法

X-RAY DIFFRACTION (1.84 Å)