6ZST

Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 3-(3-methoxyquinoxalin-2-yl)propanoic acid

Summary for 6ZST

• Entry DOI: 10.2210/pdb6zst/pdb
• Descriptor: Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE, POTASSIUM ION, ... (7 entities in total)
• Functional Keywords: fragment binding, redox enzyme, inhibitor, protein binding
• Biological source: Schistosoma mansoni
• Total number of polymer chains: 1
• Total formula weight: 66721.56

Authors

Fata, F.,Silvestri, I.,Williams, D.L.,Angelucci, F. (deposition date: 2020-07-16, release date: 2021-05-19, Last modification date: 2024-01-31)

• Primary citation: Fata, F.,Silvestri, I.,Ardini, M.,Ippoliti, R.,Di Leandro, L.,Demitri, N.,Polentarutti, M.,Di Matteo, A.,Lyu, H.,Thatcher, G.R.J.,Petukhov, P.A.,Williams, D.L.,Angelucci, F.; Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments.; Acs Infect Dis., 7:1932-1944, 2021; PubMed: 33950676; DOI: 10.1021/acsinfecdis.0c00909

Experimental method

X-RAY DIFFRACTION (1.7 Å)