6ZRP

Crystal structure of class D Beta-lactamase OXA-48 in complex with meropenem

Summary for 6ZRP

• Entry DOI: 10.2210/pdb6zrp/pdb
• Related: 6ZRG 6ZRH 6ZRI 6ZRJ
• Descriptor: Beta-lactamase, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: beta-lactamase, chdl, oxa-48, carbapenem, meropenem, acylenzyme, hydrolase
• Biological source: Klebsiella pneumoniae; More
• Total number of polymer chains: 4
• Total formula weight: 124429.55

Authors

Tassone, G.,De Luca, F.,Pozzi, C.,Di Pisa, F.,Benvenuti, M.,Mangani, S.,Doquier, J.D. (deposition date: 2020-07-14, release date: 2021-07-21, Last modification date: 2024-01-31)

• Primary citation: Tassone, G.,De Luca, F.,Pozzi, C.,Di Pisa, F.,Benvenuti, M.,Mangani, S.,Doquier, J.D.; Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.74 Å)