6ZRG
Crystal structure of OXA-10loop48 in complex with hydrolyzed doripenem
Summary for 6ZRG
Entry DOI | 10.2210/pdb6zrg/pdb |
Descriptor | Beta-lactamase, (4R,5S)-3-{[(3S,5S)-5-({[amino(dihydroxy)methyl]amino}methyl)pyrrolidin-3-yl]sulfanyl}-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | beta-lactamase, oxa-10loop48, carbapenem, doripenem, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 56157.29 |
Authors | Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Docquier, J.D.,Mangani, S. (deposition date: 2020-07-13, release date: 2021-07-21, Last modification date: 2024-01-31) |
Primary citation | Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Docquier, J.D.,Mangani, S. Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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