6ZRC
Structure of the human RBAP48 in complex with a macrocyclic peptide cyclized via a xylene linker attached to two cysteines
Summary for 6ZRC
Entry DOI | 10.2210/pdb6zrc/pdb |
Descriptor | Histone-binding protein RBBP4, macrocyclic peptide based on residues 659-672 of the metastasis-associated protein MTA1, PARA-XYLENE, ... (4 entities in total) |
Functional Keywords | nurd, histone binding domain, wd40 domain, beta propeller, chromatin regulator, macrocyclic peptide, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 99239.77 |
Authors | Vetter, I.R.,Porfetye, A.T. (deposition date: 2020-07-13, release date: 2020-10-28, Last modification date: 2024-01-31) |
Primary citation | Hart, P.'.,Hommen, P.,Noisier, A.,Krzyzanowski, A.,Schuler, D.,Porfetye, A.T.,Akbarzadeh, M.,Vetter, I.R.,Adihou, H.,Waldmann, H. Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48. Angew.Chem.Int.Ed.Engl., 60:1813-1820, 2021 Cited by PubMed: 33022847DOI: 10.1002/anie.202009749 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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