6ZR9

The crystal structure of the complex of hCAVII with 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide

6ZR9 の概要

• エントリーDOI: 10.2210/pdb6zr9/pdb
• 分子名称: Carbonic anhydrase 7, ZINC ION, 2-[4-(diphenylmethyl)piperazin-1-yl]-~{N}-(4-sulfamoylphenyl)ethanamide, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase vii, protein-inhibitor complex, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31455.68

構造登録者

D'Ambrosio, K.,De Simone, G.,Di Fiore, A. (登録日: 2020-07-11, 公開日: 2021-06-16)

• 主引用文献: D'Ambrosio, K.,Di Fiore, A.,Buonanno, M.,Kumari, S.,Tiwari, M.,Supuran, C.T.,Mishra, C.B.,Monti, S.M.,De Simone, G.; The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development; New J.Chem., 45:147-152, 2021; DOI: 10.1039/D0NJ03544K

実験手法

X-RAY DIFFRACTION (2.05 Å)