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6ZOT

Crystal structure of YTHDF3 YTH domain in complex with m6A RNA

Summary for 6ZOT
Entry DOI10.2210/pdb6zot/pdb
DescriptorYTH domain-containing family protein 3, RNA (3 entities in total)
Functional Keywordsythdf3, m6a, complex, rna binding protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight48170.54
Authors
Bedi, R.K.,Caflisch, A. (deposition date: 2020-07-07, release date: 2020-10-28, Last modification date: 2024-01-31)
Primary citationLi, Y.,Bedi, R.K.,Moroz-Omori, E.V.,Caflisch, A.
Structural and Dynamic Insights into Redundant Function of YTHDF Proteins.
J.Chem.Inf.Model., 60:5932-5935, 2020
Cited by
PubMed Abstract: Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N-methyladenosine (mA) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with mA-containing RNA using X-ray crystallography and molecular dynamics (MD). The new X-ray structures and MD simulations show that the three proteins share identical interactions with the mA-containing RNA and have similar intrinsic plasticity, thus evidencing the redundant roles of the three proteins in cellular functions.
PubMed: 33073985
DOI: 10.1021/acs.jcim.0c01029
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

243531

数据于2025-10-22公开中

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