6ZOT

Crystal structure of YTHDF3 YTH domain in complex with m6A RNA

6ZOT の概要

• エントリーDOI: 10.2210/pdb6zot/pdb
• 分子名称: YTH domain-containing family protein 3, RNA (3 entities in total)
• 機能のキーワード: ythdf3, m6a, complex, rna binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48170.54

構造登録者

Bedi, R.K.,Caflisch, A. (登録日: 2020-07-07, 公開日: 2020-10-28, 最終更新日: 2024-01-31)

主引用文献

Li, Y.,Bedi, R.K.,Moroz-Omori, E.V.,Caflisch, A.
Structural and Dynamic Insights into Redundant Function of YTHDF Proteins.
J.Chem.Inf.Model., 60:5932-5935, 2020

PubMed Abstract: Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N-methyladenosine (mA) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with mA-containing RNA using X-ray crystallography and molecular dynamics (MD). The new X-ray structures and MD simulations show that the three proteins share identical interactions with the mA-containing RNA and have similar intrinsic plasticity, thus evidencing the redundant roles of the three proteins in cellular functions.

PubMed: 33073985
DOI: 10.1021/acs.jcim.0c01029

実験手法

X-RAY DIFFRACTION (2.7 Å)