6ZMN
Crystal structure of the Smad3-Smad5 MH1 domain chimera bound to the GGCGC site
Summary for 6ZMN
Entry DOI | 10.2210/pdb6zmn/pdb |
Related | 5od6 5odg 6btz 6tce |
Descriptor | Mothers against decapentaplegic homolog 3, DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), ACETATE ION, ... (7 entities in total) |
Functional Keywords | smad3, transcription, tgfbeta, dimerization, hinge loop, protein engineering, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 39548.66 |
Authors | Pluta, R.,Macias, M.J. (deposition date: 2020-07-03, release date: 2020-08-26, Last modification date: 2024-01-31) |
Primary citation | Ruiz, L.,Kaczmarska, Z.,Gomes, T.,Aragon, E.,Torner, C.,Freier, R.,Baginski, B.,Martin-Malpartida, P.,de Martin Garrido, N.,Marquez, J.A.,Cordeiro, T.N.,Pluta, R.,Macias, M.J. Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes. Comput Struct Biotechnol J, 19:632-646, 2021 Cited by PubMed: 33510867DOI: 10.1016/j.csbj.2020.12.044 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.333 Å) |
Structure validation
Download full validation report