6ZMN

Crystal structure of the Smad3-Smad5 MH1 domain chimera bound to the GGCGC site

Summary for 6ZMN

• Entry DOI: 10.2210/pdb6zmn/pdb
• Related: 5od6 5odg 6btz 6tce
• Descriptor: Mothers against decapentaplegic homolog 3, DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP*GP*CP*A)-3'), ACETATE ION, ... (7 entities in total)
• Functional Keywords: smad3, transcription, tgfbeta, dimerization, hinge loop, protein engineering, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 39548.66

Authors

Pluta, R.,Macias, M.J. (deposition date: 2020-07-03, release date: 2020-08-26, Last modification date: 2024-01-31)

• Primary citation: Ruiz, L.,Kaczmarska, Z.,Gomes, T.,Aragon, E.,Torner, C.,Freier, R.,Baginski, B.,Martin-Malpartida, P.,de Martin Garrido, N.,Marquez, J.A.,Cordeiro, T.N.,Pluta, R.,Macias, M.J.; Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes.; Comput Struct Biotechnol J, 19:632-646, 2021; PubMed: 33510867; DOI: 10.1016/j.csbj.2020.12.044

Experimental method

X-RAY DIFFRACTION (2.333 Å)