6ZLJ

Crystal Structure of UDP-Glucuronic acid 4-epimerase Y149F mutant from Bacillus cereus in complex with UDP-4-DEOXY-4-FLUORO-Glucuronic acid and NAD

6ZLJ の概要

• エントリーDOI: 10.2210/pdb6zlj/pdb
• 分子名称: Epimerase domain-containing protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (2~{R},3~{S},4~{R},5~{R},6~{R})-6-[[[(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidany l)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3-fluoranyl-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: epimerase, udp-4-deoxy-4-fluoro-glucuronic acid, nad, oxidoreductase, udp-sugar binding protein
• 由来する生物種: Bacillus cereus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75513.32

構造登録者

Iacovino, L.G.,Mattevi, A. (登録日: 2020-06-30, 公開日: 2020-07-29, 最終更新日: 2024-01-31)

• 主引用文献: Iacovino, L.G.,Savino, S.,Borg, A.J.E.,Binda, C.,Nidetzky, B.,Mattevi, A.; Crystallographic snapshots of UDP-glucuronic acid 4-epimerase ligand binding, rotation, and reduction.; J.Biol.Chem., 295:12461-12473, 2020; PubMed: 32661196; DOI: 10.1074/jbc.RA120.014692

実験手法

X-RAY DIFFRACTION (1.7 Å)