6ZJZ
Discovery of M5049: a novel selective TLR7/8 inhibitor for treatment of autoimmunity
Summary for 6ZJZ
Entry DOI | 10.2210/pdb6zjz/pdb |
Descriptor | Toll-like receptor 8, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | leucine rich repeat, rna, glycosylation, innate immunity, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 190947.93 |
Authors | Musil, D.,Lehman, M.,Strauss, J. (deposition date: 2020-06-29, release date: 2020-12-30, Last modification date: 2024-01-31) |
Primary citation | Vlach, J.,Bender, A.T.,Przetak, M.,Pereira, A.,Deshpande, A.,Johnson, T.L.,Reissig, S.,Tzvetkov, E.,Musil, D.,Morse, N.T.,Haselmayer, P.,Zimmerli, S.C.,Okitsu, S.L.,Walsky, R.L.,Sherer, B. Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity. J.Pharmacol.Exp.Ther., 376:397-409, 2021 Cited by PubMed: 33328334DOI: 10.1124/jpet.120.000275 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.489 Å) |
Structure validation
Download full validation report