6ZGW

Structure of human galactokinase 1 bound with (4-chlorophenyl)methyl pyridine-3-carboxylate

6ZGW の概要

• エントリーDOI: 10.2210/pdb6zgw/pdb
• 分子名称: Galactokinase, beta-D-galactopyranose, 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, ... (5 entities in total)
• 機能のキーワード: galk1, galactokinase 1, fragment screening, allosteric fragment, binding hotspt, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 174251.29

構造登録者

Mackinnon, S.R.,Bezerra, G.A.,Zhang, M.,Foster, W.,Krojer, T.,Brandao-Neto, J.,Douangamath, A.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Brennan, P.,Lai, K.,Yue, W.W. (登録日: 2020-06-20, 公開日: 2020-07-29, 最終更新日: 2024-01-24)

• 主引用文献: Mackinnon, S.R.,Krojer, T.,Foster, W.R.,Diaz-Saez, L.,Tang, M.,Huber, K.V.M.,von Delft, F.,Lai, K.,Brennan, P.E.,Arruda Bezerra, G.,Yue, W.W.; Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.; Acs Chem.Biol., 16:586-595, 2021; PubMed: 33724769; DOI: 10.1021/acschembio.0c00498

実験手法

X-RAY DIFFRACTION (2.3 Å)