6ZGM

Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with the thiazolecarboxylate inhibitor ANT2681

6ZGM の概要

• エントリーDOI: 10.2210/pdb6zgm/pdb
• 分子名称: Metallo-beta-lactamase VIM-2-like protein, ZINC ION, ACETATE ION, ... (5 entities in total)
• 機能のキーワード: metallo-beta-lactamase, triazole-thione inhibitor, antibiotic resistance, carbapenem-hydrolyzing beta-lactamase, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26289.02

構造登録者

Docquier, J.D.,Pozzi, C.,Marcoccia, F.,De Luca, F.,Benvenuti, M.,Mangani, S. (登録日: 2020-06-19, 公開日: 2020-09-02, 最終更新日: 2024-01-24)

• 主引用文献: Davies, D.T.,Leiris, S.,Sprynski, N.,Castandet, J.,Lozano, C.,Bousquet, J.,Zalacain, M.,Vasa, S.,Dasari, P.K.,Pattipati, R.,Vempala, N.,Gujjewar, S.,Godi, S.,Jallala, R.,Sathyap, R.R.,Darshanoju, N.A.,Ravu, V.R.,Juventhala, R.R.,Pottabathini, N.,Sharma, S.,Pothukanuri, S.,Holden, K.,Warn, P.,Marcoccia, F.,Benvenuti, M.,Pozzi, C.,Mangani, S.,Docquier, J.D.,Lemonnier, M.,Everett, M.; ANT2681: SAR Studies Leading to the Identification of a Metallo-beta-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-ProducingEnterobacteriaceae.; Acs Infect Dis., 6:2419-2430, 2020; PubMed: 32786279; DOI: 10.1021/acsinfecdis.0c00207

実験手法

X-RAY DIFFRACTION (1.65 Å)