6ZFZ

Structure of M1-StaR-T4L in complex with 77-LH-28-1 at 2.17A

6ZFZ の概要

• エントリーDOI: 10.2210/pdb6zfz/pdb
• 分子名称: Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1, 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one, OLEIC ACID, ... (8 entities in total)
• 機能のキーワード: gpcr, 7tm, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55411.76

構造登録者

Rucktooa, P.,Cooke, R.M. (登録日: 2020-06-18, 公開日: 2021-10-06, 最終更新日: 2024-01-24)

• 主引用文献: Brown, A.J.H.,Bradley, S.J.,Marshall, F.H.,Brown, G.A.,Bennett, K.A.,Brown, J.,Cansfield, J.E.,Cross, D.M.,de Graaf, C.,Hudson, B.D.,Dwomoh, L.,Dias, J.M.,Errey, J.C.,Hurrell, E.,Liptrot, J.,Mattedi, G.,Molloy, C.,Nathan, P.J.,Okrasa, K.,Osborne, G.,Patel, J.C.,Pickworth, M.,Robertson, N.,Shahabi, S.,Bundgaard, C.,Phillips, K.,Broad, L.M.,Goonawardena, A.V.,Morairty, S.R.,Browning, M.,Perini, F.,Dawson, G.R.,Deakin, J.F.W.,Smith, R.T.,Sexton, P.M.,Warneck, J.,Vinson, M.,Tasker, T.,Tehan, B.G.,Teobald, B.,Christopoulos, A.,Langmead, C.J.,Jazayeri, A.,Cooke, R.M.,Rucktooa, P.,Congreve, M.S.,Weir, M.,Tobin, A.B.; From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.; Cell, 184:5886-, 2021; PubMed: 34822784; DOI: 10.1016/j.cell.2021.11.001

実験手法

X-RAY DIFFRACTION (2.17 Å)