6Z9D

Human Ecto-5'-nucleotidase (CD73) in complex with AOPCP derivative AB680 (compound 55 in publication) in the closed form (crystal form III)

6Z9D の概要

• エントリーDOI: 10.2210/pdb6z9d/pdb
• 分子名称: 5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: zinc enzyme, nucleotide analog, inhibitor, arcus biosciences, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62452.79

構造登録者

Strater, N. (登録日: 2020-06-03, 公開日: 2020-09-16, 最終更新日: 2024-01-24)

• 主引用文献: Lawson, K.V.,Kalisiak, J.,Lindsey, E.A.,Newcomb, E.T.,Leleti, M.R.,Debien, L.,Rosen, B.R.,Miles, D.H.,Sharif, E.U.,Jeffrey, J.L.,Tan, J.B.L.,Chen, A.,Zhao, S.,Xu, G.,Fu, L.,Jin, L.,Park, T.W.,Berry, W.,Moschutz, S.,Scaletti, E.,Strater, N.,Walker, N.P.,Young, S.W.,Walters, M.J.,Schindler, U.,Powers, J.P.; Discovery of AB680: A Potent and Selective Inhibitor of CD73.; J.Med.Chem., 63:11448-11468, 2020; PubMed: 32614585; DOI: 10.1021/acs.jmedchem.0c00525

実験手法

X-RAY DIFFRACTION (1.9 Å)