Summary for 6Z8P
Entry DOI | 10.2210/pdb6z8p/pdb |
Descriptor | Bromodomain-containing protein 2, 1,2-ETHANEDIOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ... (5 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14281.41 |
Authors | Chung, C. (deposition date: 2020-06-02, release date: 2020-10-21, Last modification date: 2024-05-01) |
Primary citation | Preston, A.,Atkinson, S.J.,Bamborough, P.,Chung, C.W.,Gordon, L.J.,Grandi, P.,Gray, J.R.J.,Harrison, L.A.,Lewis, A.J.,Lugo, D.,Messenger, C.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Rioja, I.,Seal, J.,Taylor, S.,Thesmar, P.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Demont, E.H. GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family. Acs Med.Chem.Lett., 11:1581-1587, 2020 Cited by PubMed: 32832027DOI: 10.1021/acsmedchemlett.0c00247 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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