6Z8P

C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH GSK973

This is a non-PDB format compatible entry.

Summary for 6Z8P

• Entry DOI: 10.2210/pdb6z8p/pdb
• Descriptor: Bromodomain-containing protein 2, 1,2-ETHANEDIOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ... (5 entities in total)
• Functional Keywords: inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14281.41

Authors

Chung, C. (deposition date: 2020-06-02, release date: 2020-10-21, Last modification date: 2024-05-01)

• Primary citation: Preston, A.,Atkinson, S.J.,Bamborough, P.,Chung, C.W.,Gordon, L.J.,Grandi, P.,Gray, J.R.J.,Harrison, L.A.,Lewis, A.J.,Lugo, D.,Messenger, C.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Rioja, I.,Seal, J.,Taylor, S.,Thesmar, P.,Wall, I.D.,Watson, R.J.,Woolven, J.M.,Demont, E.H.; GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family.; Acs Med.Chem.Lett., 11:1581-1587, 2020; PubMed: 32832027; DOI: 10.1021/acsmedchemlett.0c00247

Experimental method

X-RAY DIFFRACTION (1.55 Å)