6Z83

CK2 alpha bound to chemical probe SGC-CK2-1

This is a non-PDB format compatible entry.

Summary for 6Z83

• Entry DOI: 10.2210/pdb6z83/pdb
• Descriptor: Casein kinase II subunit alpha, SULFATE ION, ~{N}-[5-[[3-cyano-7-(cyclopropylamino)-3~{H}-pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methyl-phenyl]propanamide, ... (5 entities in total)
• Functional Keywords: kinase, chemical probe, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 88245.72

Authors

Kraemer, A.,Wells, C.,Drewry, D.H.,Pickett, J.E.,Axtman, A.D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-06-02, release date: 2020-07-29, Last modification date: 2024-01-24)

• Primary citation: Wells, C.I.,Drewry, D.H.,Pickett, J.E.,Tjaden, A.,Kramer, A.,Muller, S.,Gyenis, L.,Menyhart, D.,Litchfield, D.W.,Knapp, S.,Axtman, A.D.; Development of a potent and selective chemical probe for the pleiotropic kinase CK2.; Cell Chem Biol, 28:546-558.e10, 2021; PubMed: 33484635; DOI: 10.1016/j.chembiol.2020.12.013

Experimental method

X-RAY DIFFRACTION (2.171 Å)