6Z7G

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH N-(2-(1H-imidazol-4-yl)ethyl)-4-acetamido-3-(benzyloxy)benzamide

これはPDB形式変換不可エントリーです。

6Z7G の概要

• エントリーDOI: 10.2210/pdb6z7g/pdb
• 分子名称: Bromodomain-containing protein 4, N-(2-(1H-imidazol-4-yl)ethyl)-4-acetamido-3-(benzyloxy)benzamide (3 entities in total)
• 機能のキーワード: inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15477.80

構造登録者

Chung, C. (登録日: 2020-05-30, 公開日: 2020-07-29, 最終更新日: 2024-05-15)

• 主引用文献: Preston, A.,Atkinson, S.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Jones, E.J.,Lindon, M.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Seal, J.,Taylor, S.,Wall, I.,Watson, R.J.,Woolven, J.,Demont, E.H.; Design and Synthesis of a Highly Selective andIn Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins.; J.Med.Chem., 63:9070-9092, 2020; PubMed: 32691591; DOI: 10.1021/acs.jmedchem.0c00605

実験手法

X-RAY DIFFRACTION (1.59 Å)