6Z7F
C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-(2-(1H-imidazol-4-yl)ethyl)-4-acetamido-3-(benzyloxy)benzamide
This is a non-PDB format compatible entry.
Summary for 6Z7F
Entry DOI | 10.2210/pdb6z7f/pdb |
Descriptor | Bromodomain-containing protein 2, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | inhibitor, histone, epigenetic reader, bromodomain, brd2, bromodomain containing protein 2, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14147.26 |
Authors | Chung, C. (deposition date: 2020-05-30, release date: 2020-07-29, Last modification date: 2024-05-15) |
Primary citation | Preston, A.,Atkinson, S.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Jones, E.J.,Lindon, M.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Seal, J.,Taylor, S.,Wall, I.,Watson, R.J.,Woolven, J.,Demont, E.H. Design and Synthesis of a Highly Selective andIn Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins. J.Med.Chem., 63:9070-9092, 2020 Cited by PubMed: 32691591DOI: 10.1021/acs.jmedchem.0c00605 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.605 Å) |
Structure validation
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