6Z6A

Keap1 macrocycle complex

Summary for 6Z6A

Entry DOI	10.2210/pdb6z6a/pdb
Descriptor	Kelch-like ECH-associated protein 1, (5S,8R)-8-[[(2S)-1-ethanoylpyrrolidin-2-yl]carbonylamino]-N,N-dimethyl-7,11-bis(oxidanylidene)-10-oxa-3-thia-6-azabicyclo[10.4.0]hexadeca-1(16),12,14-triene-5-carboxamide, SODIUM ION, ... (5 entities in total)
Functional Keywords	macrocycle, complex, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	64678.75
Authors	Johansson, P. (deposition date: 2020-05-28, release date: 2020-12-30, Last modification date: 2024-01-24)
Primary citation	Begnini, F.,Poongavanam, V.,Over, B.,Castaldo, M.,Geschwindner, S.,Johansson, P.,Tyagi, M.,Tyrchan, C.,Wissler, L.,Sjo, P.,Schiesser, S.,Kihlberg, J. Mining Natural Products for Macrocycles to Drug Difficult Targets. J.Med.Chem., 64:1054-1072, 2021 Cited by PubMed: 33337880 DOI: 10.1021/acs.jmedchem.0c01569 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation