6Z4Q

Crystal structure of the neurotensin receptor 1 in complex with the small-molecule inverse agonist SR142948A

This is a non-PDB format compatible entry.

Summary for 6Z4Q

• Entry DOI: 10.2210/pdb6z4q/pdb
• Related: 6YVR
• Descriptor: Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin, 2-[[5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methyl-carbamoyl]-2-propan-2-yl-phenyl]pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid (2 entities in total)
• Functional Keywords: gpcr-ligand complex, rntsr1, sr142948a, inverse agonist, membrane protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 1
• Total formula weight: 53775.07

Authors

Deluigi, M.,Klipp, A.,Hilge, M.,Merklinger, L.,Klenk, C.,Plueckthun, A. (deposition date: 2020-05-25, release date: 2021-02-10, Last modification date: 2024-01-24)

• Primary citation: Deluigi, M.,Klipp, A.,Klenk, C.,Merklinger, L.,Eberle, S.A.,Morstein, L.,Heine, P.,Mittl, P.R.E.,Ernst, P.,Kamenecka, T.M.,He, Y.,Vacca, S.,Egloff, P.,Honegger, A.,Pluckthun, A.; Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.; Sci Adv, 7:-, 2021; PubMed: 33571132; DOI: 10.1126/sciadv.abe5504

Experimental method

X-RAY DIFFRACTION (2.923 Å)