6Z4M
A4V mutant of human SOD1 bound with 2-(pyridin-3-ylmethyl)benzoisoselenazolone derivative 10 in P21 space group
This is a non-PDB format compatible entry.
Summary for 6Z4M
Entry DOI | 10.2210/pdb6z4m/pdb |
Descriptor | Superoxide dismutase [Cu-Zn], ~{N}-[(6-methoxypyridin-3-yl)methyl]-2-selanyl-benzamide, ZINC ION, ... (6 entities in total) |
Functional Keywords | sod1, ebselen, motor neuron disease, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32782.30 |
Authors | Amporndanai, K.,Hasnain, S.S. (deposition date: 2020-05-25, release date: 2020-09-16, Last modification date: 2024-01-24) |
Primary citation | Amporndanai, K.,Rogers, M.,Watanabe, S.,Yamanaka, K.,O'Neill, P.M.,Hasnain, S.S. Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis. Ebiomedicine, 59:102980-102980, 2020 Cited by PubMed: 32862101DOI: 10.1016/j.ebiom.2020.102980 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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