6Z46

Structure of the S. acidocaldarius 20S proteasome (Saci0613/Saci0662)

6Z46 の概要

• エントリーDOI: 10.2210/pdb6z46/pdb
• 分子名称: Proteasome subunit alpha, Proteasome subunit beta (2 entities in total)
• 機能のキーワード: 20s, proteasome, archaea, sulfolobus acidocaldarius, hydrolase
• 由来する生物種: Sulfolobus acidocaldarius; 詳細
• タンパク質・核酸の鎖数: 28
• 化学式量合計: 677876.25

構造登録者

Robinson, N.P.,Bray, S.M. (登録日: 2020-05-22, 公開日: 2020-08-05, 最終更新日: 2024-01-24)

主引用文献

Tarrason Risa, G.,Hurtig, F.,Bray, S.,Hafner, A.E.,Harker-Kirschneck, L.,Faull, P.,Davis, C.,Papatziamou, D.,Mutavchiev, D.R.,Fan, C.,Meneguello, L.,Arashiro Pulschen, A.,Dey, G.,Culley, S.,Kilkenny, M.,Souza, D.P.,Pellegrini, L.,de Bruin, R.A.M.,Henriques, R.,Snijders, A.P.,Saric, A.,Lindas, A.C.,Robinson, N.P.,Baum, B.
The proteasome controls ESCRT-III-mediated cell division in an archaeon.
Science, 369:-, 2020

PubMed Abstract: is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in , we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III-mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control.

PubMed: 32764038
DOI: 10.1126/science.aaz2532

実験手法

X-RAY DIFFRACTION (3.698 Å)