6Z3V

A4V mutant of human SOD1 bound with N-aryl benzoisoselenazolone derivative 13 in P21 space group

これはPDB形式変換不可エントリーです。

6Z3V の概要

• エントリーDOI: 10.2210/pdb6z3v/pdb
• 分子名称: Superoxide dismutase [Cu-Zn], ZINC ION, 5-fluoranyl-~{N}-(3-morpholin-4-ylcarbonylphenyl)-2-selanyl-benzamide, ... (5 entities in total)
• 機能のキーワード: sod1, motor neuron disease, ebselen, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33267.77

構造登録者

Amporndanai, K.,Hasnain, S.S. (登録日: 2020-05-22, 公開日: 2020-09-16, 最終更新日: 2024-01-24)

主引用文献

Amporndanai, K.,Rogers, M.,Watanabe, S.,Yamanaka, K.,O'Neill, P.M.,Hasnain, S.S.
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis.
Ebiomedicine, 59:102980-102980, 2020

PubMed Abstract: Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease as well as Lou Gehrig's disease, is a progressive neurological disorder selectively affecting motor neurons with no currently known cure. Around 20% of the familial ALS cases arise from dominant mutations in the sod1 gene encoding superoxide dismutase1 (SOD1) enzyme. Aggregation of mutant SOD1 in familial cases and of wild-type SOD1 in at least some sporadic ALS cases is one of the known causes of the disease. Riluzole, approved in 1995 and edaravone in 2017 remain the only drugs with limited therapeutic benefits.

PubMed: 32862101
DOI: 10.1016/j.ebiom.2020.102980

実験手法

X-RAY DIFFRACTION (1.25 Å)