6Z3G
Repulsive Guidance Molecule A (RGMA) in complex with Growth Differentiation Factor 5 (GDF5)
Summary for 6Z3G
| Entry DOI | 10.2210/pdb6z3g/pdb |
| Descriptor | Growth/differentiation factor 5, Repulsive guidance molecule A, CITRIC ACID (3 entities in total) |
| Functional Keywords | repulsive guidance molecule, rgm, bone morphogenetic protein, bmp, growth differentiation factor 5, gdf5, neogenin, axon guidance, tgfbeta signalling, brain development, iron metabolism., signaling protein |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 25226.44 |
| Authors | Malinauskas, T.,Peer, T.V.,Bishop, B.,Muller, T.D.,Siebold, C. (deposition date: 2020-05-20, release date: 2020-07-01, Last modification date: 2024-01-24) |
| Primary citation | Malinauskas, T.,Peer, T.V.,Bishop, B.,Mueller, T.D.,Siebold, C. Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proc.Natl.Acad.Sci.USA, 117:15620-15631, 2020 Cited by PubMed: 32576689DOI: 10.1073/pnas.2000561117 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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