6Z3F

VEGF-A 13:107 crystallized with 2C bicyclic peptide

Summary for 6Z3F

Entry DOI	10.2210/pdb6z3f/pdb
Descriptor	Chains: P, Vascular endothelial growth factor A, AMINO GROUP, ... (6 entities in total)
Functional Keywords	growth factor, peptide ligand, lactam bridge, alpha-helix stabilization, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	24628.36
Authors	Gaucher, J.-F.,Broussy, S.,Reille-Seroussi, M. (deposition date: 2020-05-20, release date: 2021-06-02, Last modification date: 2024-05-01)
Primary citation	Gaucher, J.F.,Reille-Seroussi, M.,Broussy, S. Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands. Chemistry, 2022 Cited by PubMed: 35665969 DOI: 10.1002/chem.202200465 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation