6Z2V
CLK3 A319V mutant bound with beta-carboline KH-CARB13 (Cpd 3)
Summary for 6Z2V
Entry DOI | 10.2210/pdb6z2v/pdb |
Descriptor | Dual specificity protein kinase CLK3, (4~{S})-7,8-bis(chloranyl)-9-methyl-1-oxidanylidene-spiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrile, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, clk3, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42810.87 |
Authors | Schroeder, M.,Chaikuad, A.,Bracher, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-05-18, release date: 2020-07-29, Last modification date: 2024-01-24) |
Primary citation | Schroder, M.,Bullock, A.N.,Fedorov, O.,Bracher, F.,Chaikuad, A.,Knapp, S. DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. J.Med.Chem., 63:10224-10234, 2020 Cited by PubMed: 32787076DOI: 10.1021/acs.jmedchem.0c00898 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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