6Z23
Acylenzyme complex of cefotaxime bound to deacylation mutant KPC-2 (E166Q)
Summary for 6Z23
| Entry DOI | 10.2210/pdb6z23/pdb |
| Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | unliganded beta-lactamase, 3-layer alpha-beta-alpha sandwich, part of the dd-peptidase and beta-lactamase superfamily., antimicrobial protein |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 31867.58 |
| Authors | Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2020-05-14, release date: 2020-12-23, Last modification date: 2024-01-24) |
| Primary citation | Tooke, C.L.,Hinchliffe, P.,Bonomo, R.A.,Schofield, C.J.,Mulholland, A.J.,Spencer, J. Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance. J.Biol.Chem., 296:100126-100126, 2020 Cited by PubMed: 33257320DOI: 10.1074/jbc.RA120.016461 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.31 Å) |
Structure validation
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