6YZN

Closo-carborane butyl-sulfonamide in complex with CA IX mimic

6YZN の概要

• エントリーDOI: 10.2210/pdb6yzn/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, Carborane closo-butyl-sulfonamide, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase, ca inhibitor, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29534.62

構造登録者

Kugler, M.,Brynda, J.,Pospisilova, K.,Rezacova, P. (登録日: 2020-05-07, 公開日: 2020-10-28, 最終更新日: 2024-01-24)

• 主引用文献: Kugler, M.,Holub, J.,Brynda, J.,Pospisilova, K.,Anwar, S.E.,Bavol, D.,Havranek, M.,Kral, V.,Fabry, M.,Gruner, B.,Rezacova, P.; The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.; J Enzyme Inhib Med Chem, 35:1800-1810, 2020; PubMed: 32962427; DOI: 10.1080/14756366.2020.1816996

実験手法

X-RAY DIFFRACTION (0.95 Å)