6YYK
Crystal Structure of 1,5-dimethylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C
Summary for 6YYK
Entry DOI | 10.2210/pdb6yyk/pdb |
Descriptor | Tyrosine-protein kinase BTK, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | btk, covalent fragments, surface entrophy reduction, crystal engineering, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 40198.55 |
Authors | Brear, P.,Wagstaff, J.,Hyvonen, M. (deposition date: 2020-05-05, release date: 2021-05-12, Last modification date: 2024-01-24) |
Primary citation | Brear, P.,Fischer, G.,May, M.,Pantelejevs, T.,Mathieu, R.,Rossmann, M.,Wagstaff, J.,Blaszczyk, B.,Hyvonen, M. Optimising crystallographic systems for structure-guided drug discovery To Be Published, |
Experimental method |
Structure validation
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