6YYF

Crystal Structure of 5-chloroindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C

Summary for 6YYF

• Entry DOI: 10.2210/pdb6yyf/pdb
• Descriptor: Tyrosine-protein kinase BTK, 5-chloranyl-1,3-dihydroindol-2-one, ZINC ION, ... (5 entities in total)
• Functional Keywords: btk, covalent fragments, surface entrophy reduction, crystal engineering, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 40372.54

Authors

Brear, P.,Wagstaff, J.,Hyvonen, M. (deposition date: 2020-05-05, release date: 2021-05-12, Last modification date: 2024-01-24)

• Primary citation: Brear, P.,Fischer, G.,May, M.,Pantelejevs, T.,Mathieu, R.,Rossmann, M.,Wagstaff, J.,Blaszczyk, B.,Hyvonen, M.; Optimising crystallographic systems for structure-guided drug discovery; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.93 Å)