6YXP

Higher resolution structure of the N-terminal module of the human SWI/SNF-subunit BAF155/SMARCC1

6YXP の概要

• エントリーDOI: 10.2210/pdb6yxp/pdb
• 分子名称: SWI/SNF complex subunit SMARCC1 (2 entities in total)
• 機能のキーワード: baf155, swi/snf-subunit, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65708.39

構造登録者

Allen, M.D.,Bycroft, M.,Zinzalla, G. (登録日: 2020-05-03, 公開日: 2021-04-21, 最終更新日: 2024-01-24)

主引用文献

Allen, M.D.,Freund, S.M.V.,Bycroft, M.,Zinzalla, G.
SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.
Commun Biol, 4:528-528, 2021

PubMed Abstract: SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here we show that the N-terminus of the BAF155/SMARCC1 subunit contains a putative DNA-binding MarR-like domain, a chromodomain and a BRCT domain that are interconnected to each other to form a distinct module. In this structure the chromodomain makes interdomain interactions and has lost its canonical function to bind to methylated lysines. The structure provides new insights into the missense mutations that target this module in cancer. This study also reveals two adjacent, highly-conserved pockets in a cleft between the domains that form a potential binding site, which can be targeted with small molecules, offering a new strategy to target SWI/SNF complexes.

PubMed: 33953332
DOI: 10.1038/s42003-021-02050-z

実験手法

X-RAY DIFFRACTION (1.6 Å)