6YVW
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with monocyclic BB-328
6YVW の概要
エントリーDOI | 10.2210/pdb6yvw/pdb |
関連するPDBエントリー | 4BQW 4BQX 4BQY 5A3U |
分子名称 | Egl nine homolog 1, FE (III) ION, 4-[(5-bromanyl-4,6-dimethyl-pyridin-2-yl)amino]-4-oxidanylidene-butanoic acid, ... (5 entities in total) |
機能のキーワード | oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 28546.02 |
構造登録者 | |
主引用文献 | Chowdhury, R.,Abboud, M.I.,McAllister, T.E.,Banerji, B.,Bhushan, B.,Sorensen, J.L.,Kawamura, A.,Schofield, C.J. Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2. Sci Rep, 10:21964-21964, 2020 Cited by PubMed: 33319810DOI: 10.1038/s41598-020-76307-8 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.97 Å) |
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