6YUM

CK2 alpha bound to unclosed Macrocycle

This is a non-PDB format compatible entry.

Summary for 6YUM

• Entry DOI: 10.2210/pdb6yum/pdb
• Descriptor: Casein kinase II subunit alpha, SULFATE ION, 4-[5-[2-(2-hydroxyethyloxy)ethyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pyrazolo[1,5-a]pyrimidin-3-yl]-2-oxidanyl-benzoic acid, ... (4 entities in total)
• Functional Keywords: kinase, macrocycle, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 91910.42

Authors

Kraemer, A.,Hanke, T.,Kurz, C.,Celik, I.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-04-27, release date: 2020-07-01, Last modification date: 2024-01-24)

• Primary citation: Kramer, A.,Kurz, C.G.,Berger, B.T.,Celik, I.E.,Tjaden, A.,Greco, F.A.,Knapp, S.,Hanke, T.; Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor.; Eur.J.Med.Chem., 208:112770-112770, 2020; PubMed: 32883634; DOI: 10.1016/j.ejmech.2020.112770

Experimental method

X-RAY DIFFRACTION (2.75 Å)