6YTY

CLK3 A319V mutant bound with benzothiazole Tg003 (Cpd 2)

Summary for 6YTY

Entry DOI	10.2210/pdb6yty/pdb
Descriptor	Dual specificity protein kinase CLK3, 1,2-ETHANEDIOL, (1~{Z})-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one, ... (4 entities in total)
Functional Keywords	inhibitor, complex, clk3, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42657.86
Authors	Schroeder, M.,Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-04-24, release date: 2020-07-15, Last modification date: 2024-01-24)
Primary citation	Schroder, M.,Bullock, A.N.,Fedorov, O.,Bracher, F.,Chaikuad, A.,Knapp, S. DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. J.Med.Chem., 63:10224-10234, 2020 Cited by PubMed: 32787076 DOI: 10.1021/acs.jmedchem.0c00898 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation