6YRP
Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with JMV-4690 (Cpd 31)
Summary for 6YRP
Entry DOI | 10.2210/pdb6yrp/pdb |
Descriptor | Metallo-beta-lactamase VIM-2-like protein, ZINC ION, 2-[[[3-(5-methoxy-2-oxidanyl-phenyl)-5-sulfanylidene-1~{H}-1,2,4-triazol-4-yl]amino]methyl]benzoic acid, ... (7 entities in total) |
Functional Keywords | metallo-beta-lactamase, triazole-thione inhibitor, antibiotic resistance, carbapenem-hydrolyzing beta-lactamase, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 26490.37 |
Authors | Docquier, J.D.,Pozzi, C.,De Luca, F.,Benvenuti, M.,Mangani, S. (deposition date: 2020-04-20, release date: 2020-09-30, Last modification date: 2024-01-24) |
Primary citation | Gavara, L.,Sevaille, L.,De Luca, F.,Mercuri, P.,Bebrone, C.,Feller, G.,Legru, A.,Cerboni, G.,Tanfoni, S.,Baud, D.,Cutolo, G.,Bestgen, B.,Chelini, G.,Verdirosa, F.,Sannio, F.,Pozzi, C.,Benvenuti, M.,Kwapien, K.,Fischer, M.,Becker, K.,Frere, J.M.,Mangani, S.,Gresh, N.,Berthomieu, D.,Galleni, M.,Docquier, J.D.,Hernandez, J.F. 4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 208:112720-112720, 2020 Cited by PubMed: 32937203DOI: 10.1016/j.ejmech.2020.112720 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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