6YQW

BRD9 with 4-chloro-2-methyl-methylamino-pyridazinone

6YQW の概要

• エントリーDOI: 10.2210/pdb6yqw/pdb
• 分子名称: Bromodomain-containing protein 9, 4-chloranyl-2-methyl-5-(methylamino)pyridazin-3-one (3 entities in total)
• 機能のキーワード: brd9, inhibitor, histone, epigenetic reader, bromodomain, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12401.80

構造登録者

Chung, C. (登録日: 2020-04-18, 公開日: 2021-04-14, 最終更新日: 2024-05-01)

• 主引用文献: Clegg, M.A.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Gordon, L.,Grandi, P.,Leveridge, M.,Lindon, M.,Liwicki, G.M.,Michon, A.M.,Molnar, J.,Rioja, I.,Soden, P.E.,Theodoulou, N.H.,Werner, T.,Tomkinson, N.C.O.,Prinjha, R.K.,Humphreys, P.G.; Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.; J.Med.Chem., 63:5816-5840, 2020; PubMed: 32410449; DOI: 10.1021/acs.jmedchem.0c00075

実験手法

X-RAY DIFFRACTION (1.5 Å)