6YQO

Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW12

6YQO の概要

• エントリーDOI: 10.2210/pdb6yqo/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, (S)-N1-(4-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)phenyl)-N8-hydroxyoctanediamide, ... (4 entities in total)
• 機能のキーワード: bromodomain, brd4(bd1), dual bromodomain hdac inhibitor, structural genomics consortium, sgc, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15947.78

構造登録者

Joerger, A.C.,Balourdas, D.I.,Weiser, T.,Chatterjee, D.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-04-17, 公開日: 2020-05-06, 最終更新日: 2024-01-24)

• 主引用文献: Zhang, X.,Zegar, T.,Weiser, T.,Hamdan, F.H.,Berger, B.T.,Lucas, R.,Balourdas, D.I.,Ladigan, S.,Cheung, P.F.,Liffers, S.T.,Trajkovic-Arsic, M.,Scheffler, B.,Joerger, A.C.,Hahn, S.A.,Johnsen, S.A.,Knapp, S.,Siveke, J.T.; Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma.; Int.J.Cancer, 147:2847-2861, 2020; PubMed: 32599645; DOI: 10.1002/ijc.33137

実験手法

X-RAY DIFFRACTION (1.07 Å)